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KMID : 0364519930040020195
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Dong-A Journal Medicine
1993 Volume.4 No. 2 p.195 ~ p.202
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Effect of Intravenous Anesthetics on systemic Vascular Resistance during Cardiopulmonary Bypass
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Abstract
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We have studied the effect of thiopental sodium, propofol, midazolam and ketamine on systemic vascular resistance(SVR) during cardiopulmonary bypass with constant pump flow in 20 patients undergoing elective open heart surgery.
SVR decreased about 13(±3.42)% of control values after thiopental sodium 4mg/kg, about 10(±5.30%) of control after propofol 2mg/kg and about 8(±3.72)% of control after midazolam 0.2mg/kg; it returned to control values abut 2 min 30sec(±1min
20sec)
after administration of the thiopental sodium and about 4 min 30 sec(±2 min 15 sec) after administration of propofol.
It remained under control values after 10 min after administration of midazolam. Ketamine showed no significant changes on SVR. Analysis of variance showed that there were no significant differences in the changes in SVR between the groups.
Change
of
SVR after administration of thiopental sodium did not statistical significant (P<0.05).
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